刘博，男，汉族，黑龙江省哈尔滨市人，1985年5月生，中共党员，副教授，博士生导师，关于在线登录入口副经理。内蒙古自治区高等学校“青年科技英才支持计划”和内蒙古自治区“草原英才”工程青年创新创业人才计划一层次入选者；中国畜牧兽医学会兽医内科与临床诊疗学分会常务理事，国家自然科学基金委员会生命科学部农业动物科学处兽医学科项目函评专家，教育部学位中心全国专业学位（兽医学科）水平评估学位论文质量评价专家；Food & Function、Frontiers in Immunology和Microbiology Spectrum等SCI期刊审稿人，Frontiers in Cellular and Infection Microbiology期刊客座编辑；主要研究方向为奶牛产后细菌感染性疾病发病机理和诊断防治。

一、教育及工作经历

2008年毕业于东北林业大学野生动物资源学院动物医学专业，获得学士学位；

2013年硕博连读毕业于吉林大学动物医学学院临床兽医学专业，获得博士学位；

2013年通过高层次人才引进计划（第五层次A类）进入关于在线登录入口临床兽医学内科诊断教研室工作。

二、主持科研项目和人才奖励项目情况（国家级3项、自治区级7项、校级3项）

[1]国家自然科学基金项目，布劳恩脂蛋白对大肠杆菌诱导的奶牛子宫内膜炎症反应的调控机制研究，项目号32160854，2022.01-2025.12，35万元，主持；

[2]国家自然科学基金项目，PGE₂和PGF_2α对奶牛子宫内膜上皮细胞促增殖作用及其机制研究，项目号31860722，2019.01-2022.12，39万元，主持；

[3]国家自然科学基金项目，PGE₂和PGF_2α对奶牛子宫内膜上皮细胞TLR2、TLR4及RP105参与的信号转导通路激活的调控，项目号31560714，2016.01-2019.12，49.2万元，主持；

[4] 2022年度内蒙古自治区“草原英才”工程青年创新创业人才计划，创新人才一层次，15万元，主持（自治区级人才奖励项目）；

[5] 2020年度内蒙古自治区“草原英才”工程青年创新创业人才计划，创新人才二层次，5万元，主持（自治区级人才奖励项目）；

[6] 2018年度内蒙古自治区高等学校“青年科技英才支持计划”，项目号NJYT-18-B03，2018.01-2019.12，农业，20万元，主持（自治区级人才奖励项目）；

[7]内蒙古自治区直属高校基本科研业务费项目，基于肠道菌群挖掘大肠杆菌所致小鼠子宫内膜炎的调控机制，项目号BR231510，2023.01-2025.12，20万元，主持；

[8]中央引导地方科技发展资金项目，肠道菌群对大肠杆菌所致小鼠子宫内膜炎的调控机制研究，项目号2022ZY0200，2022.09-2025.08，10万元，主持；

[9]内蒙古自治区人才开发基金，PGF_2α和PGE₂对奶牛乳腺上皮细胞TLRs介导的天然免疫应答的调控作用，5万元，主持；

[10]内蒙古自治区自然科学基金项目，PGF_2α和PGE₂在奶牛子宫内膜上皮细胞中对TLRs介导的天然免疫的调控，项目号2014BS0323，2014.01-2016.12，3万元，主持；

[11]bat365官方网站优秀青年科学基金培养项目，金黄色葡萄球菌脂蛋白在TLRs及NLRP3炎性复合体介导的小鼠巨噬细胞激活中的作用研究，项目号2017XYQ-2，2018.01-2020.12，29万元，主持；

[12]bat365官方网站优秀青年科学基金项目，PGF_2α和PGE₂在奶牛乳腺上皮细胞TLRs介导的天然免疫中的调控作用，项目号2014XYQ-3，2014.10-2017.10，15万元，主持；

[13]bat365官方网站引进人才科研启动基金，PGF_2α和PGE₂对金葡菌在奶牛乳腺上皮细胞中的存活和细胞天然免疫应答的影响，项目号YJ2014-3，2015.01-2017.12，10万元，主持

三、第一作者和通讯作者署名论文发表情况（^*通讯作者，^#共同第一作者）

SCI论文：

[1] Prostaglandin D₂regulatesEscherichia coli-induced inflammatory responses through TLR2, TLR4, and NLRP3 in macrophages.Gong Z^#, Mao W^#, Jin F^#, Zhang S, Zhao J, Ren P, Yu Z, Bai Y, Wang C, Cao J^*,Liu B^*.Prostaglandins Other Lipid Mediat. 2023 Sep 3;169:106772.

[2] Besides TLR2 and TLR4, NLRP3 is also involved in regulatingEscherichia coliinfection-induced inflammatory responses in mice.Shen Y^#, Gong Z^#, Zhang S^#, Cao J, Mao W, Yao Y, Zhao J, Li Q, Liu K,Liu B^*, Feng S^*.Int Immunopharmacol. 2023 Aug;121:110556.

[3] Braun Lipoprotein Protects againstEscherichia coli-Induced Inflammatory Responses and Lethality in Mice.Shen Y^#, Gong Z^#, Zhang S^#, Cao J, Mao W, Fu Y, Su N, Ding Y, Zhao J, Gu B, Feng S^*,Liu B^*.Microbiol Spectr. 2023 Mar 14;11(2):e0354122.

[4] TLR2, TLR4, and NLRP3 mediated the balance between host immune-driven resistance and tolerance inStaphylococcus aureus-infected mice. Gong Z, Zhang J, Zhang S, Cao J, Fu Y, Hu X, Zhao J, Gu B, Li Q, Zhang K, Ren P,Liu B^*, Mao W^*. Microb Pathog. 2022 Aug;169:105671.

[5] Codonopsis pilosula polysaccharides attenuateEscherichia coli-induced acute lung injury in mice. Gong Z^#, Zhang S^#, Gu B^#, Cao J, Mao W, Yao Y, Zhao J, Ren P, Zhang K,Liu B^*. Food Funct. 2022 Aug 1;13(15):7999-8011.

[6]Staphylococcus aureuslipoproteins play crucial roles in inducing inflammatory responses and bacterial internalization into bovine mammary epithelial cells.Liu B, Li Q, Gong Z, Zhao J, Gu B, Feng S^*.Microb Pathog. 2022 Jan;162:105364.

[7] Prostaglandin E receptor 2 mediates the inducible effects of prostaglandin E₂on expression of growth factors and enzymes in cattle endometrial epithelial cells and explants.Zhang S, Li Q, Mao W, Zhao J, Gong Z,Liu B^*, Cao J^*.Anim Sci J. 2022 Jan-Dec;93(1):e13766.

[8] Proliferation of bovine endometrial epithelial cells is promoted by prostaglandin E₂-PTGER2 signaling through cell cycle regulation.Liu B, Fu C, Cao J, Mao W, Zhang S, Li Q, Zhao J, Feng S^*. Prostaglandins Leukot Essent Fatty Acids. 2021 Nov;174:102362.

[9] Lipopolysaccharide stimulates bovine endometrium explants through toll‑like receptor 4 signaling and PGE₂synthesis. Deng Y^#,Liu B^#, Fu C, Gao L, Shen Y, Liu K, Li Q, Cao J^*, Mao W^*. Prostaglandins Leukot Essent Fatty Acids. 2021 May;168:102272.

[10] 17β-estradiol regulates prostaglandin E₂and F_2αsynthesis and function in endometrial explants of cattle. Li Q^#, Zhang S^#, Mao W, Fu C, Shen Y, Wang Y, Liu B^*, Cao J^*. Anim Reprod Sci. 2020 May;216:106466.

[11] Prostaglandin F_2α-PTGFR signaling promotes proliferation of endometrial epithelial cells of cattle through cell cycle regulation.Fu C, Mao W, Gao R, Deng Y, Gao L, Wu J, Zhang S, Shen Y, Liu K, Li Q, Song X, Cao J^*,Liu B^*.Anim Reprod Sci. 2020 Feb;213:106276.

[12] Prostaglandin E₂Regulates Activation of Mouse Peritoneal Macrophages byStaphylococcus aureusthrough TLR2, TLR4, and NLRP3 Inflammasome Signaling. Jindi Wu,Bo Liu^*, Wei Mao, Shuang Feng, Yuan Yao, Fan Bai, Yuan Shen, Amu Guleng, Bayin Jirigala, Jinshan Cao^*. J Innate Immun. 2020;12(2):154-169.

[13] Regulatory roles of PGE₂in LPS-induced tissue damage in bovine endometrial explants. Deng Y^#,Liu B^#, Mao W^#, Shen Y, Fu C, Gao L, Zhang S, Wu J, Li Q, Li T, Liu K, Cao J^*.Eur J Pharmacol. 2019 Mar 28;852:207-217.

[14] Prostaglandin E₂promotes Pam3CSK4-induced inflammation in endometrial epithelial cells of cattle.Yuan Shen^#, Shuang Feng^#,Bo Liu^*,#,Wei Mao, Ruifeng Gao, Jindi Wu, Yang Deng, Long Gao, Shuangyi Zhang, Qianru Li, Jinshan Cao^*. Anim Reprod Sci. 2019 Jan;200:51-59.

[15] PGE₂downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells. Shen Y^#,Liu B^*,#, Mao W, Gao R, Feng S, Qian Y, Wu J, Zhang S, Gao L, Fu C, Li Q, Deng Y, Cao J^*.Prostaglandins Leukot Essent Fatty Acids. 2018 Feb;129:25-31.

[16] Concentration effect of prostaglandin E₂on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics. Zhang S^#, Mao W^#, Li Q, Gao R, Zhang Y, Gao L, Fu C, Wu J, Deng Y, Shen Y, Li T,Liu B^*, Cao J^*. Reprod Domest Anim. 2018 Feb;53(1):143-151.

[17] PTGER2 activation induces PTGS-2 and growth factor gene expression in endometrial epithelial cells of cattle. Gao L^#,Liu B^#, Mao W, Gao R, Zhang S, Duritahala, Fu C, Shen Y, Zhang Y, Zhang N, Wu J, Deng Y, Wu X, Cao J^*. Anim Reprod Sci. 2017 Dec;187:54-63.

[18] Prostaglandin F_2α-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Zhang S^#,Liu B^#, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J^*. Reprod Fertil Dev. 2017 Oct;29(11):2195-2205.

[19] The effect of prostaglandin E₂receptor (PTGER2) activation on growth factor expression and cell proliferation in bovine endometrial explants. Zhang S^#,Liu B^#, Mao W, Li Q, Fu C, Zhang N, Zhang Y, Gao L, Shen Y, Cao J^*.Prostaglandins Leukot Essent Fatty Acids. 2017 Jul;122:16-23.

[20] Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle. Huang N^#,Liu B^#, Dong Z, Mao W, Zhang N, Li C, Cao J^*.Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):170-175.

[21] Involvement of RP105 and Toll-like receptors in the activation of mouse peritoneal macrophages byStaphylococcus aureus.Bo Liu, Yunhe Fu, Shuang Feng, Xichen Zhang, Zhicheng Liu, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Naisheng Zhang, Zhengtao Yang^*. Scand J Immunol. 2013 Jul;78(1):8-16.

[22] RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.Bo Liu, Naisheng Zhang, Zhicheng Liu, Yunhe Fu, Shuang Feng, Shan Wang, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Xiaojing Song, Zhengtao Yang^*. Molecular and Cellular Biochemistry. 2013 Jun; 378(1-2):183-93.

[23] Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Fu Y^#,Liu B^#, Liu J, Liu Z, Liang D, Li F, Li D, Cao Y, Zhang X, Zhang N^*, Yang Z^*. IntImmunopharmacol. 2012 Dec;14(4):792-8.

[24] The effect of magnolol on the Toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice. Yunhe F^#,Bo L^#, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z^*, Zhengtao Y^*. Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61.

核心期刊论文：

[1]冯爽,赵佳敏,巩志国,刘博^*,张双翼^*.PTGER2激活对奶牛子宫内膜组织中生长因子表达的影响[J].中国兽医学报,2023,43(07):1491-1496+1505.

[2]巩志国,赵佳敏,顾柏臣,任佩佩,于琢雅,白云洁,刘鑫煜,王超,刘博^*.基于网络药理学分析党参减轻大肠杆菌感染小鼠急性肺损伤的作用机制[J].畜牧兽医学报,2023,54(08):3571-3581.

[3]李成应,巩志国,张双翼,刘博^*,毛伟^*.在LPS诱导的天然免疫反应中前列腺素D₂与TLR2和TLR4的相互调控作用[J].中国兽医学报,2023,43(06):1277-1283.

[4]任佩佩,巩志国,张兰欣,顾柏臣,赵佳敏,高飞菲,刘博^*.TLR2和NLRP3对大肠杆菌诱导的细胞因子分泌、脏器损伤和小鼠死亡的调控作用[J].中国兽医学报,2022,42(09):1798-1804.

[5]赵佳敏,李茜如,高飞菲,巩志国,顾柏臣,白云洁,刘博^*. NLRP3在介导小鼠皮肤伤口修复过程中的作用[J].中国兽医学报,2022,42(04):733-739.

[6]巩志国,顾柏臣,沈媛,李茜如,金凤,赵佳敏,刘博^*.布劳恩脂蛋白对大肠埃希氏菌感染导致的小鼠体内细胞因子分泌及死亡的调节作用[J].动物医学进展,2022,43(02):25-29.

[7]金凤,李茜如,巩志国,顾柏臣,赵佳敏,曹金山,刘博^*.前列腺素D₂对大肠杆菌诱导的小鼠巨噬细胞细胞因子分泌的影响[J].中国兽医学报,2021,41(09):1746-1751.

[8]冯爽,张双翼,李茜如,赵佳敏,巩志国,刘博^*.前列腺素F_2α-PTGFR通路的激活对奶牛子宫内膜组织中生长因子表达的影响[J].中国兽医学报,2021,41(05):968-974.

[9]刘博,沈媛,毛伟,高瑞峰,曹金山^*.前列腺素E₂和F_2α对LPS刺激后奶牛子宫内膜上皮细胞COX-1和COX-2表达的影响[J].中国畜牧兽医,2017,44(09):2716-2723.

四、专著和教材出版情况

[1]高瑞峰，刘博，毛伟，贺鹏飞，冯爽，李慧萍，张良，杨慧娣，张欣，钱英红.主编.常见鹿病诊断与防治技术.中国农业出版社.2019.12。

[2]刘宗平，赵宝玉等，参编。兽医内科学（精简版）.中国农业出版社.全国高等教育农业农村部“十三五”规划教材，全国高等农林院校“十三五”规划教材.2021.01。

五、软件著作权

毛伟，曹金山，刘博，何秀玲，高瑞峰，贺鹏飞.兽医远程诊断系统V3.0.登记号：2021SR0415743. 2021.03.18